Ozenoxacin
Xepi (ozenoxacin) is a topical antibiotic cream used to treat impetigo, a common bacterial skin infection characterized by red sores or blisters. It is approved for use in adults and children 2 months of age and older, and is typically applied to the affected area twice daily for 5 days.
Xepi is a topical antibiotic cream that treats impetigo skin infections caused by certain bacteria.
Key facts at a glance
- RxNorm
- 1994746
- Generic
- Xepi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Xepi is indicated for the topical treatment of impetigo (including bullous impetigo and non-bullous impetigo) caused by Staphylococcus aureus or Streptococcus pyogenes in adults and pediatric patients 2 months of age and older.
Xepi contains ozenoxacin, a quinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication, thereby stopping the growth of bacteria.
Xepi is for topical use only and should not be ingested or applied to the eyes, nose, mouth, or mucous membranes. Common side effects may include application site reactions such as irritation, redness, or itching. Patients with a history of hypersensitivity to quinolone antibiotics should use caution. Treatment should be limited to 5 days as directed by a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy