Acyclovir / Hydrocortisone
Xerese is a topical prescription medication combining acyclovir (an antiviral) and hydrocortisone (a corticosteroid) to treat recurrent herpes labialis (cold sores). It is indicated for use in immunocompetent adults and children 6 years of age and older.
Xerese is a topical cream used to treat cold sores by combining an antiviral agent with an anti-inflammatory steroid.
Key facts at a glance
- RxNorm
- 998423
- Generic
- Xerese
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Xerese is indicated for the topical treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and pediatric patients 6 years of age and older.
Xerese contains two active ingredients: acyclovir, which inhibits replication of the herpes simplex virus, and hydrocortisone, which reduces inflammation associated with cold sore lesions. The combination helps reduce healing time and may prevent lesion progression.
Xerese is for topical use only and should be applied at the first sign of a cold sore. It is not indicated for prevention of cold sore outbreaks or for use in immunocompromised patients. Avoid contact with eyes and mucous membranes. The medication should not be used by those with known hypersensitivity to any of its components.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy