Telotristat Ethyl
Xermelo (telotristat ethyl) is a prescription medication used to treat diarrhea caused by carcinoid syndrome in adults whose symptoms are not adequately controlled with somatostatin analog therapy. It works by inhibiting an enzyme involved in serotonin production, helping to reduce the frequency of diarrhea episodes. This oral medication is typically added to existing treatment regimens when standard therapies prove insufficient.
Xermelo is an oral medication for carcinoid syndrome diarrhea in adults when other treatments are not fully controlling symptoms.
Key facts at a glance
- RxNorm
- 1872484
- Generic
- Xermelo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Xermelo is indicated for the treatment of carcinoid syndrome diarrhea in adults who are not adequately controlled with somatostatin analog therapy. It may be used alone or in combination with other medications for carcinoid syndrome management.
Xermelo inhibits tryptophan hydroxylase, an enzyme responsible for converting tryptophan to 5-hydroxytryptophan in the serotonin synthesis pathway. By reducing serotonin production, it helps control the diarrhea associated with carcinoid syndrome.
Xermelo is a brand-name medication with no available generic equivalent. Common side effects may include nausea, abdominal pain, and elevated liver enzymes. Patients should be monitored for constipation, as serious cases of severe constipation have been reported. Always follow prescribing physician instructions and report any concerning symptoms promptly.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy