Denosumab
Xgeva is a brand-name medication containing denosumab, a monoclonal antibody that inhibits RANK ligand to reduce bone breakdown. It is primarily used to prevent skeletal-related events such as fractures in patients with cancer that has spread to the bones, treat giant cell tumor of bone in adults and eligible adolescents, and manage hypercalcemia of malignancy.
Xgeva is used to prevent bone complications in cancer patients with bone metastases and treat certain bone tumors.
Key facts at a glance
- RxNorm
- 1046399
- Generic
- Xgeva
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevents bone complications (fractures, spinal compression, radiation/surgery to bone) in patients with solid tumors metastatic to bone; treats adults and skeletally mature adolescents with giant cell tumor of bone that is unresectable or where surgery would be harmful; treats hypercalcemia of malignancy refractory to bisphosphonates.
Denosumab binds to RANK ligand (RANKL), a protein essential for bone-removing cells (osteoclasts), preventing RANKL from activating its receptor and thereby reducing bone destruction.
Carries risk of hypocalcemia, especially in patients with kidney impairment; associated with osteonecrosis of the jaw (ONJ); not for patients with hypocalcemia; must be given by subcutaneous injection by a healthcare professional; patients should maintain adequate calcium and vitamin D intake.
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy