Collagenase Clostridium Histolyticum
Xiaflex is a prescription injectable medication containing collagenase enzymes that break down abnormal collagen tissue. It is used to treat adults with Dupuytren's contracture (a hand condition causing finger bending) and Peyronie's disease (a penile condition causing curvature).
Xiaflex is an injectable enzyme therapy used to treat hand and penile conditions involving abnormal collagen buildup.
Key facts at a glance
- RxNorm
- 898496
- Generic
- Xiaflex
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Xiaflex treats Dupuytren's contracture in adults with a palpable cord, and Peyronie's disease in adults with measurable plaque and curvature deformity.
It contains collagenase enzymes derived from Clostridium histolyticum bacteria that enzymatically break down collagen when injected directly into abnormal tissue cords or plaques.
Must be administered by a qualified healthcare professional; a follow-up finger manipulation procedure is performed 1-3 days after injection for Dupuytren's. Potential risks include tendon/ligament injury, injection site reactions, and allergic reactions. Not for intravascular use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy