Lifitegrast
Xiidra (lifitegrast) is a prescription eye drop medication used to treat the signs and symptoms of dry eye disease in adults. It works by reducing inflammation on the surface of the eye to help restore normal tear production and improve eye comfort.
Xiidra is a prescription eye drop for adults with dry eye disease that reduces inflammation to relieve dryness, irritation, and discomfort.
Key facts at a glance
- RxNorm
- 1801836
- Generic
- Xiidra
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Xiidra is FDA-approved for the treatment of both signs and symptoms of dry eye disease in adults. Signs include corneal staining and other objective measures of eye surface damage, while symptoms include dryness, burning, stinging, irritation, and discomfort.
Xiidra contains the active ingredient lifitegrast, which is an integrin receptor antagonist. It works by blocking LFA-1 (lymphocyte function-associated antigen-1), a protein on the surface of inflammatory cells that normally allows them to adhere to other cells and tissues. By blocking this interaction, Xiidra prevents inflammatory cells from reaching the eye surface, reducing inflammation and associated damage.
Xiidra is applied as one drop in each eye twice daily. Common side effects may include eye irritation, discomfort, blurred vision, and unusual taste sensation. Patients should remove contact lenses before use and wait at least 15 minutes before reinserting them. Patients should inform their doctor about all medications and allergies before starting treatment. The safety and effectiveness in children has not been established.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy