Lidocaine / Epinephrine
Xylocaine With Epinephrine is a combination local anesthetic containing lidocaine and epinephrine, used to provide temporary numbness and pain relief during medical, surgical, and dental procedures. The epinephrine component constricts blood vessels, which reduces bleeding, keeps the anesthetic in place longer, and extends its duration of action. This medication is administered via injection into or near nerves and is commonly used for minor surgeries, dental work, and regional anesthesia blocks.
A local anesthetic combined with a vasoconstrictor used to numb areas during medical and dental procedures while reducing bleeding.
Key facts at a glance
- RxNorm
- 746946
- Generic
- Xylocaine With Epinephrine
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for local and regional anesthesia during minor surgical procedures, dental work (including extractions, fillings, and root canals), obstetric procedures, and diagnostic procedures. Also used for infiltration anesthesia and various nerve blocks.
Lidocaine blocks sodium channels in nerve fibers, preventing the generation and transmission of nerve impulses and thereby numbing the area. Epinephrine causes vasoconstriction at the injection site, which decreases blood flow, minimizes bleeding, slows absorption of the anesthetic, and prolongs its duration of action.
Should NOT be used in areas with end-arterial blood supply (digits, ears, nose, penis) due to risk of tissue ischemia from epinephrine-induced vasoconstriction. Maximum recommended doses must be observed to avoid toxicity. Contraindicated in patients with severe heart disease, uncontrolled hypertension, or known hypersensitivity. May interact with certain medications including beta-blockers and tricyclic antidepressants.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy