Axicabtagene Ciloleucel
Yescarta is an autologous CAR-T cell therapy for adults with certain relapsed or refractory large B-cell lymphomas. The patient's own T cells are collected, genetically modified to target cancer cells, and reinfused to fight the disease.
Yescarta is a personalized cell therapy using modified patient T cells to treat certain relapsed or refractory blood cancers.
Key facts at a glance
- RxNorm
- 1987403
- Generic
- Yescarta
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma, high-grade B-cell lymphoma, and transformed follicular lymphoma.
This is a CAR-T cell therapy where the patient's own T cells are collected and genetically engineered to express a chimeric antigen receptor (CAR) that targets CD19, a protein found on the surface of B-cell cancers. These modified cells are then infused back into the patient, where they recognize and destroy cancer cells expressing CD19.
Administered as a single infusion following lymphodepleting chemotherapy. Carries boxed warnings for cytokine release syndrome (CRS) and neurologic toxicity. Requires specialized healthcare facilities with staff trained to manage these potentially life-threatening complications. Patient enrollment in REMS program required.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy