Yohimbine
Yohimbine is an alpha-2 adrenergic antagonist derived from the bark of the yohimbe tree. It works by blocking alpha-2 receptors, which leads to increased sympathetic nervous system activity. This medication has been primarily used to treat erectile dysfunction and orthostatic hypotension, though its use has declined due to the availability of more effective alternatives.
An alpha-2 adrenergic antagonist historically used for erectile dysfunction and orthostatic hypotension.
Key facts at a glance
- ATC
- G04BE04
- RxNorm
- 220982
- Generic
- Yohimbine
- Class
- atc-g04
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Erectile dysfunction (particularly of psychogenic origin), orthostatic hypotension, and occasionally used off-label for sexual dysfunction in women.
Yohimbine is a selective alpha-2 adrenergic receptor antagonist. By blocking these receptors, it increases sympathetic outflow, promotes vasodilation in certain vascular beds, and may enhance sexual arousal by increasing norepinephrine levels and reducing inhibitory signals in sexual response pathways.
Use with caution in patients with cardiovascular disease, hypertension, or anxiety disorders due to its sympathomimetic effects. Common side effects include anxiety, insomnia, tachycardia, and hypertension. Should not be used in combination with certain antidepressants or in patients with renal impairment. Its effectiveness is considered modest and has largely been superseded by other treatments.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy