Yosprala
Yosprala is a combination medication containing aspirin and omeprazole, designed for patients requiring long-term aspirin therapy for cardiovascular protection who are also at risk for aspirin-induced stomach ulcers. The omeprazole component helps reduce stomach acid and protects the gastric lining from aspirin's irritating effects. This medication is specifically indicated for secondary prevention of cardiovascular events in patients requiring chronic aspirin therapy.
Yosprala combines aspirin with a stomach-protecting agent for patients needing long-term cardiovascular protection who are at risk for gastric ulcers.
Key facts at a glance
- RxNorm
- 1811911
- Generic
- Yosprala
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Secondary prevention of myocardial infarction (heart attack), stroke, and cardiovascular death in patients with a history of these conditions who require long-term aspirin therapy. Also used to reduce the risk of aspirin-associated gastric or duodenal ulcers.
Yosprala combines enteric-coated aspirin (an antiplatelet agent that inhibits platelet aggregation to prevent blood clots) with omeprazole (a proton pump inhibitor that reduces stomach acid production and protects the gastric mucosa from aspirin-induced damage).
Take Yosprala at least 30 minutes before a meal. Do not stop taking this medication without consulting your doctor, as abrupt discontinuation of aspirin may increase cardiovascular risk. Common side effects may include gastrointestinal discomfort, headache, and nausea. Inform your doctor of all medications you're taking to avoid drug interactions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy