YUPELRI
Yupelri (revefenacin) is a long-acting muscarinic antagonist (LAMA) bronchodilator used as maintenance treatment for chronic obstructive pulmonary disease (COPD). It is administered via nebulizer once daily to help improve breathing by relaxing airway muscles. Yupelri is the only nebulized LAMA approved for COPD management.
Yupelri is a once-daily nebulized bronchodilator used to maintain airflow and improve breathing in patients with COPD.
Key facts at a glance
- RxNorm
- 2102780
- Generic
- Yupelri
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Maintenance treatment of COPD in adults, including chronic bronchitis and emphysema. Not indicated for acute bronchospasm or asthma.
As a long-acting muscarinic antagonist (LAMA), Yupelri blocks muscarinic receptors in bronchial smooth muscle, preventing acetylcholine from causing bronchoconstriction and allowing airways to remain open for extended periods.
May cause paradoxical bronchospasm, urinary retention, or worsening of narrow-angle glaucoma. Tell your doctor about all medical conditions and medications before use. Avoid getting the solution in eyes. Common side effects include headache, back pain, and upper respiratory tract infection.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy