Zaleplon
Zaleplon is a non-benzodiazepine sedative-hypnotic medication used for the short-term treatment of insomnia, particularly difficulty falling asleep. It acts on GABA-A receptors in the brain to produce a calming effect that facilitates sleep initiation. Due to its ultra-short half-life, it is best suited for sleep-onset insomnia and should be taken at bedtime or after the patient has gone to bed if they cannot fall asleep.
Zaleplon is a short-term insomnia medication that helps initiate sleep through its action on GABA receptors in the brain.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05CF03
- RxNorm
- 74667
- Generic
- Zaleplon
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Short-term treatment of insomnia characterized by difficulty falling asleep. It is not typically indicated for sleep maintenance problems or middle-of-the-night awakenings.
Zaleplon is a selective GABA-A receptor agonist. It binds specifically to the omega-1 subunit of the GABA-A receptor complex, enhancing the inhibitory effects of GABA neurotransmitter, which results in sedation and sleep initiation.
Recommended for short-term use only (generally 2-4 weeks). May cause drowsiness, dizziness, and impaired coordination the next day. Risk of dependence increases with prolonged use. Should be taken immediately before bedtime or after going to bed when sleep onset is delayed. Patients should ensure they can get a full night's sleep (at least 4 hours) before engaging in activities requiring alertness.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy