Zanubrutinib
Zanubrutinib is a targeted cancer medication that inhibits Bruton's tyrosine kinase (BTK), a protein essential for B-cell survival and proliferation. It is used to treat various B-cell cancers including mantle cell lymphoma, Waldenström's macroglobulinemia, chronic lymphocytic leukemia, and marginal zone lymphoma.
Zanubrutinib is a BTK inhibitor used to treat certain B-cell cancers by blocking a key signaling protein needed for cancer cell survival.
Key facts at a glance
- ATC
- L01EL03
- RxNorm
- 2262435
- Generic
- Zanubrutinib
- Class
- atc-l01
- Brands
- Brukinsa
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zanubrutinib is indicated for the treatment of mantle cell lymphoma in patients who have received at least one prior therapy, Waldenström's macroglobulinemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, and marginal zone lymphoma.
Zanubrutinib is a small-molecule inhibitor that forms a covalent bond with Bruton's tyrosine kinase (BTK), blocking its active site. This inhibits BTK activity, which is critical for B-cell receptor signaling and cytokine receptor pathways, thereby disrupting B-cell proliferation and survival.
Common side effects include neutropenia, thrombocytopenia, anemia, rash, diarrhea, and musculoskeletal pain. Serious risks include atrial fibrillation, bleeding events, hypertension, and secondary malignancies. Patients should be monitored for infections and cardiac rhythm changes.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy