Zavegepant
Zavegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist used for the acute treatment of migraine attacks in adults. It belongs to a class of medications called gepants and is administered as a nasal spray, offering a non-oral option for patients who may have difficulty swallowing pills during a migraine episode.
Zavegepant is a nasal spray medication that treats acute migraine attacks by blocking CGRP receptors.
Key facts at a glance
- ATC
- N02CD08
- RxNorm
- 2637955
- Generic
- Zavegepant
- Class
- atc-n02
- Brands
- Zavzpret
- Availability
- rx
- Lactation
- unknown
- Routes
- nasal
- Forms
- spray
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Acute treatment of migraine with or without aura in adults. It is used for episodic migraine attacks and is not intended for preventive therapy or for treating other types of headaches.
Zavegepant works by blocking calcitonin gene-related peptide (CGRP) receptors. CGRP is a neuropeptide that is released during migraine attacks and contributes to inflammation and pain signaling. By antagonizing these receptors, zavegepant helps relieve migraine symptoms including headache, nausea, and sensitivity to light and sound.
Zavegepant is administered as a single nasal spray dose per attack. Common side effects may include taste disturbances, nausea, and nasal discomfort. Patients with severe hepatic or renal impairment should use caution. As with other CGRP antagonists, it should not be used with strong CYP3A4 inhibitors. Efficacy for consecutive migraine attacks should be monitored by a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy