Selegiline
Zelapar (selegiline) is a brand-name medication used as an adjunct treatment for Parkinson's disease to help improve motor function and reduce off episodes when used with levodopa/carbidopa therapy. It belongs to the monoamine oxidase-B (MAO-B) inhibitor class of medications and comes as an oral disintegrating tablet formulation.
Zelapar is an MAO-B inhibitor used alongside levodopa therapy to help manage Parkinson's disease symptoms.
Key facts at a glance
- RxNorm
- 643054
- Generic
- Zelapar
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zelapar is indicated as adjunctive treatment to levodopa/carbidopa for patients with Parkinson's disease experiencing inadequate response or wearing-off effects from levodopa monotherapy.
Zelapar is a selective, irreversible monoamine oxidase-B (MAO-B) inhibitor. By blocking the MAO-B enzyme, it prevents the breakdown of dopamine in the brain, thereby increasing dopamine levels and enhancing dopaminergic activity to help manage Parkinson's disease symptoms.
Due to the oral disintegrating tablet formulation, Zelapar may have different pharmacokinetics than other selegiline products. Patients should follow dosage instructions carefully, avoid eating or drinking until the tablet dissolves, and be aware of potential dietary tyramine interactions despite MAO-B selectivity at standard doses. Use with antidepressants requires caution due to risk of serotonin syndrome.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy