Alpha-1 Proteinase Inhibitor
Zemaira is a brand-name alpha-1 proteinase inhibitor used as augmentation therapy for patients with alpha-1 antitrypsin deficiency (AATD). It is administered intravenously to raise and maintain levels of alpha-1 antitrypsin in the blood, helping to protect the lungs from damage. This medication is specifically indicated for adults with clinically evident emphysema due to AATD.
Zemaira is an IV medication that replaces deficient alpha-1 antitrypsin protein to slow lung damage in patients with alpha-1 antitrypsin deficiency.
Key facts at a glance
- RxNorm
- 405405
- Generic
- Zemaira
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zemaira is indicated for chronic augmentation therapy in adults with alpha-1 antitrypsin deficiency who have clinically evident emphysema. It is not a cure for the condition but is used to slow disease progression and preserve lung function.
Zemaira is a purified human alpha-1 proteinase inhibitor that works by replacing the deficient or dysfunctional AAT protein in patients with AATD. The medication is administered intravenously on a regular schedule (typically weekly) to maintain therapeutic levels of the protective protein in the bloodstream.
Zemaira is derived from human plasma and carries a risk of allergic reactions and infusion reactions. It is contraindicated in patients with a history of severe reactions to alpha-1 proteinase inhibitors or their components. Patients should be monitored during infusions, and efficacy should be assessed periodically. This is a chronic, long-term therapy that does not replace other emphysema treatments.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy