Paricalcitol
Zemplar (paricalcitol) is a synthetic vitamin D analog used to prevent and treat secondary hyperparathyroidism in patients with chronic kidney disease, including those on dialysis. It works by activating vitamin D receptors in the parathyroid gland to reduce excessive parathyroid hormone production. This medication is available in both oral and intravenous formulations.
Zemplar is a vitamin D analog that lowers parathyroid hormone levels in patients with chronic kidney disease.
Key facts at a glance
- RxNorm
- 221005
- Generic
- Zemplar
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of secondary hyperparathyroidism associated with chronic kidney disease stages 3-4 and end-stage renal disease in patients on dialysis.
As a vitamin D receptor agonist, Zemplar binds to vitamin D receptors in the parathyroid gland, suppressing PTH secretion and reducing parathyroid cell proliferation.
Requires regular monitoring of serum calcium and phosphorus levels due to risk of hypercalcemia. Available as oral capsules and IV injection. May interact with other medications affecting calcium or vitamin D metabolism.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy