Ceftolozane / Tazobactam
Zerbaxa is a combination antibiotic containing ceftolozane and tazobactam, used to treat complicated urinary tract infections and intra-abdominal infections. It is also approved for hospital-acquired and ventilator-associated bacterial pneumonia. This medication is reserved for cases caused by susceptible gram-negative bacteria, including drug-resistant strains.
Zerbaxa is a combination antibiotic used for serious bacterial infections when other treatments may not be effective.
Key facts at a glance
- RxNorm
- 1597616
- Generic
- Zerbaxa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats complicated urinary tract infections (cUTI), complicated intra-abdominal infections (cIAI), and hospital-acquired/ventilator-associated bacterial pneumonia in adults.
Ceftolozane inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, while tazobactam inhibits beta-lactamase enzymes that would normally break down the antibiotic, allowing it to work against resistant bacteria.
Administered intravenously. Should only be used when indicated and when susceptible bacteria are confirmed or suspected. Monitor for allergic reactions and potential superinfections. Dosage adjustments may be needed in patients with kidney impairment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy