Lisinopril / Hydrochlorothiazide
Zestoretic is a combination blood pressure medication that contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. It is primarily used to treat hypertension by relaxing blood vessels and reducing fluid volume in the body.
Zestoretic is a combination medication used to treat high blood pressure by combining an ACE inhibitor with a diuretic.
Key facts at a glance
- RxNorm
- 85783
- Generic
- Zestoretic
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zestoretic is used to treat hypertension (high blood pressure) in patients who require combination therapy to achieve adequate blood pressure control.
Lisinopril is an ACE inhibitor that relaxes blood vessels by blocking the angiotensin-converting enzyme, while hydrochlorothiazide is a thiazide diuretic that helps the kidneys remove excess salt and water from the body, reducing overall fluid volume.
This medication should not be used during pregnancy as it may harm the fetus. Common side effects may include dizziness, headache, cough, and increased urination. Patients should avoid potassium supplements and salt substitutes containing potassium unless directed by a physician, as the diuretic component can affect potassium levels.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy