Zestril
Zestril is a brand-name ACE inhibitor containing lisinopril, used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It relaxes blood vessels by blocking an enzyme that causes them to narrow, making it easier for the heart to pump blood throughout the body.
Zestril is an ACE inhibitor used to treat high blood pressure, heart failure, and post-heart attack care by relaxing blood vessels.
Key facts at a glance
- RxNorm
- 196472
- Generic
- Zestril
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats hypertension (high blood pressure), heart failure, and is used to improve survival rates in patients after a heart attack. May also be prescribed for diabetic kidney disease.
As an ACE inhibitor, it blocks the angiotensin-converting enzyme, which prevents the formation of angiotensin II—a hormone that causes blood vessels to narrow. This relaxes and widens blood vessels, lowering blood pressure and reducing strain on the heart.
Should not be used during pregnancy as it can harm the unborn baby. Common side effects include dry cough, dizziness, and headache. Patients with a history of angioedema or those taking aliskiren should avoid this medication. Regular monitoring of blood pressure and kidney function is recommended during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy