Bisoprolol / Hydrochlorothiazide
Ziac is a combination prescription medication used to treat high blood pressure (hypertension). It combines two active ingredients—a beta-blocker and a thiazide diuretic—to help lower blood pressure through complementary mechanisms of action.
Ziac is a combination blood pressure medication containing a beta-blocker and diuretic.
Key facts at a glance
- RxNorm
- 75038
- Generic
- Ziac
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ziac is prescribed for the management of essential hypertension (high blood pressure) in patients who require combination therapy when single-agent treatment is insufficient.
Ziac combines bisoprolol, a beta-blocker that reduces heart rate and the force of heart contractions, with hydrochlorothiazide, a thiazide diuretic that helps the kidneys eliminate excess salt and water from the body, thereby reducing overall blood volume and pressure.
Ziac may not be suitable for patients with certain heart conditions, severe kidney disease, or allergies to sulfonamide-derived drugs. Common side effects include dizziness, fatigue, and electrolyte imbalances. Patients should not discontinue abruptly without medical supervision. Regular monitoring of blood pressure, electrolytes, and kidney function is recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy