Clindamycin / Tretinoin
Ziana is a topical combination medication used to treat acne vulgaris in patients 12 years and older. It contains clindamycin, an antibiotic that reduces bacteria, and tretinoin, a retinoid that helps skin cell turnover. The medication is applied once daily to affected areas of the skin.
Ziana is a prescription topical gel combining an antibiotic and retinoid to treat acne.
Key facts at a glance
- RxNorm
- 669774
- Generic
- Ziana
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ziana is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.
Ziana combines clindamycin phosphate, which inhibits bacterial protein synthesis to reduce acne-causing bacteria, with tretinoin, a retinoid that normalizes skin cell turnover and helps prevent pore clogging.
Ziana may cause skin irritation, dryness, and increased sun sensitivity. It should not be used during pregnancy. Patients should avoid excessive sun exposure and use sunscreen. Contact with eyes, mouth, and mucous membranes should be avoided.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy