Zidebactam Dihydrate
Zidebactam Dihydrate is a next-generation beta-lactamase inhibitor belonging to the diazabicyclononane (DBO) class. It is being developed in combination with cefepime to treat serious multi-drug resistant Gram-negative bacterial infections. This agent is particularly being investigated for its activity against carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa.
Zidebactam Dihydrate is an investigational beta-lactamase inhibitor combined with cefepime for treating resistant Gram-negative infections.
Key facts at a glance
- RxNorm
- 2744814
- Generic
- Zidebactam Dihydrate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Being developed for the treatment of complicated urinary tract infections (cUTI), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) caused by multi-drug resistant Gram-negative pathogens including carbapenem-resistant Enterobacteriaceae (CRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPA).
Functions as a dual-action inhibitor by binding to penicillin-binding proteins (particularly PBP2) and inhibiting serine-beta-lactamases including ESBLs, AmpC, and KPC-type carbapenemases. When combined with cefepime, it restores and extends the activity of the beta-lactam backbone against resistant organisms.
This is an investigational medication still undergoing clinical development. Safety and efficacy profiles are being established through clinical trials. As a beta-lactamase inhibitor, it is always used in combination with a beta-lactam antibiotic and is not administered as monotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy