Ziihera
Ziihera (hertrastobart) is an investigational monoclonal antibody being studied for the treatment of various solid tumors. It targets PVRIG (Poliovirus Receptor Related Immunoglobulin Domain Containing), an immune checkpoint protein, with the goal of enhancing the body's immune response against cancer cells.
Ziihera is an experimental immunotherapy drug designed to help the immune system recognize and attack cancer cells by targeting the PVRIG checkpoint pathway.
Key facts at a glance
- RxNorm
- 2698207
- Generic
- Ziihera
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ziihera is currently under investigation for the treatment of advanced solid tumors, including but not limited to non-small cell lung cancer and other malignancies where PVRIG expression may play a role in tumor immune evasion.
Ziihera is a monoclonal antibody that binds to PVRIG, a co-inhibitory receptor expressed on T cells and natural killer cells. By blocking this pathway, it may restore and enhance anti-tumor immune activity.
Ziihera is an investigational agent not yet approved by regulatory authorities. Clinical trials are ongoing to evaluate its safety, efficacy, and optimal dosing. Common considerations include potential immune-related adverse events typical of checkpoint inhibitors. Patients should only receive this medication through qualified clinical trial protocols under specialist supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy