Triamcinolone Acetonide
Zilretta is an extended-release corticosteroid injection administered directly into the knee joint for the management of osteoarthritis pain. It provides relief for up to 12 weeks with a single injection, offering a longer duration of action compared to standard corticosteroid injections. This medication is specifically indicated for patients with knee osteoarthritis who have not responded adequately to oral pain relievers or physical therapy.
Zilretta is an extended-release knee injection that relieves osteoarthritis pain for up to 12 weeks.
Key facts at a glance
- RxNorm
- 1947125
- Generic
- Zilretta
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zilretta is indicated for the management of osteoarthritis-related knee pain in adults. It is specifically designed for intra-articular use in the knee joint for patients who have not achieved adequate relief from non-pharmacologic therapies and simple analgesics like acetaminophen or NSAIDs.
Zilretta contains triamcinolone acetonide, a synthetic corticosteroid that reduces inflammation by suppressing the immune response and inhibiting inflammatory mediators in the joint. Its extended-release formulation allows the medication to be gradually released over approximately 6 weeks, providing sustained anti-inflammatory effects and pain relief for up to 12 weeks.
Zilretta is administered as a single intra-articular injection by a healthcare professional. Common side effects may include joint pain, headache, and cold-like symptoms. It is not recommended for patients with active joint infections or those with known hypersensitivity to corticosteroids. Treatment effect may not be immediate, as pain relief typically develops over the first few weeks following injection.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy