Minocycline
Zilxi is a topical foam formulation of minocycline, a tetracycline-class antibiotic, approved for treating inflammatory lesions of papulopustular rosacea in adults. Unlike oral antibiotics, this topical approach delivers the medication directly to the skin, potentially reducing systemic side effects. It is applied once daily to affected areas of the face.
Zilxi is a topical antibiotic foam used once daily to treat inflammatory lesions associated with papulopustular rosacea.
Key facts at a glance
- RxNorm
- 2375334
- Generic
- Zilxi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zilxi is FDA-approved for treating inflammatory lesions (papules and pustules) of papulopustular rosacea in adults. It is not indicated for other types of rosacea (such as erythematotelangiectatic rosacea) or for acne vulgaris.
Minocycline, the active ingredient in Zilxi, is a tetracycline antibiotic that has anti-inflammatory and antibacterial properties. When applied topically, it reduces the bacterial load and modulates inflammatory responses in the skin that contribute to rosacea lesions. Being a foam formulation allows for even distribution across the skin surface.
Zilxi is for topical use only and should not be ingested or applied to mucous membranes, eyes, or open wounds. Common side effects may include application site reactions such as redness, dryness, or itching. As with other tetracycline antibiotics, there is a potential for antibiotic resistance with prolonged use. Patients with known hypersensitivity to tetracyclines should not use this medication. Safety in pregnancy, lactation, and children under 18 has not been established.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy