Zinc Pyrithione
Zinc Pyrithione is a broad-spectrum antimicrobial agent commonly used in topical formulations to treat various skin and scalp conditions. Its antifungal and antibacterial properties make it particularly effective against fungal infections like dandruff and seborrheic dermatitis. The medication is available in multiple forms including shampoos, creams, and soaps for convenient application.
A topical antifungal and antibacterial agent primarily used to treat dandruff, seborrheic dermatitis, and certain fungal infections.
Key facts at a glance
- ATC
- D11AX12
- RxNorm
- 11469
- Generic
- Zinc Pyrithione
- Class
- atc-d11
- Brands
- Head & Shoulders, Dial Dandruff Control, Nioxin, Selsun Blue Sensitive Scalp, Head & Shoulders Damage Treatment, Dandrene, DHS Zinc, Theraplex Z, Dermazinc, Zincon
- Availability
- otc
- Pregnancy
- C
- Lactation
- unknown
- Half-life (h)
- 0
- Onset (min)
- 0
- Duration (h)
- 0
- Routes
- topical
- Forms
- shampoo, cream, lotion, soap, bar
- Regions
- United States, European Union, Canada, Australia, United Kingdom
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of dandruff and seborrheic dermatitis of the scalp; treatment of tinea versicolor (pityriasis), tinea pedis (athlete's foot), and other fungal skin infections; may also be used for psoriasis-related scaling.
Zinc Pyrithione exerts its antimicrobial effects by disrupting fungal and bacterial cell membranes, inhibiting their growth and replication. It is particularly effective against Malassezia species of fungi, which are associated with dandruff and seborrheic dermatitis. The compound also possesses anti-inflammatory properties that help reduce associated redness and irritation.
For external use only; avoid contact with eyes and mucous membranes. Rinse thoroughly if accidental eye contact occurs. Some formulations may cause skin irritation or dryness with prolonged use. Not recommended for broken or inflamed skin unless directed by a healthcare provider. Consult a doctor if symptoms persist after regular use or worsen.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy