Zinplava
Zinplava (bezlotoxumab) is a monoclonal antibody used to prevent the recurrence of Clostridioides difficile (C. difficile) infection in adults and children at high risk for recurrence. It is administered as a single intravenous infusion alongside standard antibiotic treatment for C. difficile infection. This medication does not treat active C. difficile infection but helps protect against future episodes.
Zinplava is a monoclonal antibody given as a single IV dose to help prevent C. difficile infection from coming back in high-risk patients.
Key facts at a glance
- RxNorm
- 1855053
- Generic
- Zinplava
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of Clostridioides difficile (C. difficile) infection recurrence in adults and children 1 year of age and older who are receiving antibacterial treatment for C. diff and are at high risk for recurrence.
Zinplava is a monoclonal antibody that binds to and neutralizes C. difficile toxin B, one of the main toxins produced by the bacteria that causes tissue damage and disease symptoms.
Zinplava is given as a single 60-minute IV infusion. It is not a substitute for antibacterial therapy. Heart failure has been reported as an adverse reaction, particularly in patients with a history of heart failure. Common side effects may include nausea, pyrexia, and headache.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy