Ziprasidone
Ziprasidone is an atypical antipsychotic medication used to treat schizophrenia and bipolar disorder. It works by blocking dopamine D2 and serotonin 5HT2 receptors in the brain to help regulate mood and reduce psychotic symptoms.
An atypical antipsychotic for schizophrenia and bipolar disorder that works by blocking dopamine and serotonin receptors.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05AE04
- RxNorm
- 115698
- Generic
- Ziprasidone
- Class
- atc-n05
- Brands
- Geodon
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats schizophrenia in adults and adolescents (ages 10-17), acute manic or mixed episodes of bipolar I disorder, and is used for maintenance treatment of bipolar disorder.
Functions as an antagonist at dopamine D2 and serotonin 5HT2A receptors, modulating neurotransmitter activity to reduce symptoms of psychosis and mood instability.
Must be taken with food (500+ calories) for adequate absorption. ECG monitoring is recommended due to QT prolongation risk. May cause sedation, weight changes, or extrapyramidal symptoms. Not recommended for elderly patients with dementia-related psychosis.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy