Zohydro
Zohydro is a brand-name extended-release opioid analgesic containing hydrocodone, designed for the management of severe pain requiring continuous, around-the-clock opioid treatment. It is typically prescribed when other pain management options prove insufficient for controlling chronic or severe acute pain conditions.
Zohydro is a prescription extended-release opioid medication for managing severe pain that requires continuous opioid treatment.
Key facts at a glance
- RxNorm
- 1442523
- Generic
- Zohydro
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zohydro is indicated for the management of severe pain severe enough to require daily, around-the-clock opioid treatment when alternative pain management options are inadequate. It is not intended for use on an as-needed basis or for mild pain relief.
Zohydro contains hydrocodone, an opioid agonist that binds to mu-opioid receptors in the brain and nervous system. This binding alters the perception of pain and emotional response to discomfort, providing analgesic effects through the extended-release formulation that delivers the medication gradually over time.
Zohydro carries a significant risk of dependence, addiction, and serious or life-threatening breathing problems. It should not be used by patients with significant respiratory depression, bowel obstruction, or those takingMAO inhibitors. Due to its high abuse potential, it is classified as a Schedule II controlled substance and should be used only as directed by a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy