Doxepin
Zonalon is a topical prescription medication containing doxepin, a tricyclic antidepressant applied to the skin. It is primarily used to relieve itching (pruritus) associated with various skin conditions such as eczema, lichen simplex chronicus, and other inflammatory dermatoses. The cream is intended for short-term use on specific areas of the skin.
Zonalon is a topical cream used to treat itching from skin conditions like eczema.
Key facts at a glance
- RxNorm
- 9801
- Generic
- Zonalon
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zonalon is prescribed for the relief of pruritus (itching) associated with inflammatory skin conditions, including atopic dermatitis, lichen simplex chronicus, eczema, and other dermatoses. It is used when itching does not respond adequately to other treatments.
The active ingredient doxepin is a potent antihistamine (H1 receptor antagonist). When applied topically, it blocks histamine receptors in the skin, which helps reduce itching and provides a soothing effect. It may also have mild local anesthetic properties.
Zonalon is for external use only on intact skin and should not be applied to broken or blistered skin. It may cause drowsiness, so caution is advised when applying to large areas of the body due to potential systemic absorption. Common side effects include local burning, stinging, or skin irritation. Use is generally recommended for short-term treatment only.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy