Zonisamide
Zonegran (zonisamide) is a prescription anticonvulsant medication used primarily as an adjunctive treatment for partial seizures in adults with epilepsy. It belongs to the sulfonamide class of drugs and is typically prescribed when other seizure medications alone have not provided adequate control. This medication requires a valid prescription and should only be used under the supervision of a healthcare provider experienced in treating epilepsy.
Zonegran is an anticonvulsant medication used to help control partial seizures in adults with epilepsy.
Key facts at a glance
- RxNorm
- 261708
- Generic
- Zonegran
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zonegran is FDA-approved as adjunctive therapy for the treatment of partial seizures in adults with epilepsy. It is used when monotherapy (single medication) has not achieved sufficient seizure control. It may be considered for off-label use in other seizure types or in pediatric populations in some cases, though this should be determined by a treating physician.
The exact mechanism of action of zonisamide is not fully understood. It is believed to work by blocking voltage-gated sodium channels and T-type calcium channels, which helps reduce abnormal electrical activity in the brain that leads to seizures. It may also have some effect on dopaminergic and serotonergic neurotransmitter systems.
Zonegran can cause serious side effects including metabolic acidosis, kidney stones, drowsiness, and suicidal thoughts. It is contraindicated in patients with sulfonamide allergies. Common side effects include dizziness, drowsiness, loss of appetite, and weight loss. Patients should not stop taking this medication abruptly without medical supervision, as this may increase seizure frequency. Regular monitoring of blood pH and kidney function may be recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy