Zongertinib
Zongertinib is a targeted therapy medication classified as a HER2 kinase inhibitor. It is designed to treat patients with non-small cell lung cancer that has specific mutations in the HER2 gene. By blocking HER2 signaling, it helps slow or stop cancer cell growth.
Zongertinib is an oral HER2-targeted kinase inhibitor used to treat HER2-mutant non-small cell lung cancer.
Key facts at a glance
- ATC
- L01EH04
- RxNorm
- 2721604
- Generic
- Zongertinib
- Class
- atc-l01e
- Brands
- Hernexeos
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zongertinib is used to treat HER2-mutant non-small cell lung cancer (NSCLC). It is specifically indicated for patients whose tumors harbor mutations in the HER2 (ERBB2) tyrosine kinase domain.
Zongertinib works by inhibiting the HER2 receptor, preventing its phosphorylation and blocking downstream signaling pathways including ERK. This action inhibits tumor cell proliferation in cancers that depend on HER2 signaling for growth.
As a HER2-targeted therapy, zongertinib is used based on biomarker testing for HER2 mutations. Common side effects may include gastrointestinal symptoms and skin reactions. Patients should have confirmed HER2 mutation status before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy