Vorapaxar
Zontivity (vorapaxar) is an antiplatelet medication used to reduce the risk of thrombotic cardiovascular events such as heart attack, stroke, and cardiovascular death in patients with a prior heart attack or peripheral arterial disease. It works by blocking a specific receptor on platelets involved in blood clot formation. This medication is typically used in combination with other antiplatelet drugs like aspirin.
Zontivity is an antiplatelet drug used to prevent heart attacks and strokes in patients with prior cardiovascular events or peripheral arterial disease.
Key facts at a glance
- RxNorm
- 1537040
- Generic
- Zontivity
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zontivity is indicated to reduce the risk of thrombotic cardiovascular events in adult patients with a history of heart attack (myocardial infarction) or peripheral arterial disease (PAD). It is not approved for use in patients who have had a stroke or transient ischemic attack (TIA).
Zontivity contains the active ingredient vorapaxar, which is a protease-activated receptor-1 (PAR-1) antagonist. It works by blocking PAR-1 receptors on platelets, preventing thrombin-mediated platelet activation and aggregation, thereby reducing the formation of blood clots.
Zontivity carries a boxed warning for bleeding risk, including serious and sometimes fatal bleeding. It is contraindicated in patients with active pathological bleeding or a history of stroke, TIA, or intracranial hemorrhage. Bleeding risk is increased when combined with other anticoagulants or antiplatelet agents. Patients should not discontinue the medication without consulting their healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy