Diclofenac
Zorvolex is a topical nonsteroidal anti-inflammatory drug (NSAID) patch containing diclofenac epolamine as its active ingredient. It is primarily used to provide temporary relief of acute pain associated with minor strains, sprains, and contusions. The medication is applied directly to the skin over the painful area, allowing the active ingredient to penetrate and reduce inflammation and pain at the source.
Topical NSAID patch for temporary relief of acute pain from minor muscle injuries.
Key facts at a glance
- RxNorm
- 1442117
- Generic
- Zorvolex
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zorvolex is indicated for the treatment of acute pain from minor strains, sprains, and contusions. It is designed for short-term use and is applied topically to the affected area to provide localized pain relief.
As an NSAID, diclofenac epolamine works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins—chemicals that contribute to inflammation, pain, and fever. By reducing prostaglandin production at the application site, it helps alleviate pain and inflammation in the affected tissues.
Zorvolex is for external use only and should not be applied to broken skin, eyes, or mucous membranes. Common side effects may include skin reactions at the application site such as redness, itching, or rash. Patients with aspirin or NSAID allergies, pregnant women in late pregnancy, or those taking other NSAIDs should consult their healthcare provider before use. As with all NSAIDs, there is a potential risk of systemic side effects, particularly with prolonged use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy