Roflumilast
Zoryve (roflumilast) is a topical phosphodiesterase 4 (PDE4) inhibitor used to treat plaque psoriasis in adults and children 12 years and older. By inhibiting PDE4, it reduces inflammatory responses in the skin that contribute to psoriasis symptoms, helping to clear plaques and reduce associated itching and scaling.
Topical treatment for plaque psoriasis that reduces skin inflammation through PDE4 enzyme inhibition.
Key facts at a glance
- RxNorm
- 2608535
- Generic
- Zoryve
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zoryve is FDA-approved for the topical treatment of plaque psoriasis in adults and pediatric patients 12 years of age and older. It is applied as a foam for scalp psoriasis and as a cream for plaque psoriasis on the body.
Zoryve contains roflumilast, a phosphodiesterase 4 (PDE4) inhibitor. It works by blocking the PDE4 enzyme, which increases levels of cyclic AMP (cAMP) inside cells. This leads to reduced production of pro-inflammatory mediators and decreased inflammatory responses in the skin.
Zoryve is for topical use only and should not be used in or around the eyes, mouth, or vagina. It is generally well-tolerated with a low systemic absorption profile. The foam formulation is designed for scalp application, while the cream is for body areas. Patients should follow their healthcare provider's instructions for application frequency and duration of treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy