Piperacillin/Tazobactam
Zosyn is an injectable combination antibiotic containing piperacillin and tazobactam. It is used to treat serious bacterial infections in hospitalized patients, including pneumonia, bloodstream infections, and intra-abdominal infections. This broad-spectrum medication works against many different types of bacteria.
Zosyn is an injectable antibiotic used to treat serious bacterial infections in hospital settings.
Key facts at a glance
- RxNorm
- 74170
- Generic
- Zosyn
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zosyn treats a range of serious infections including nosocomial pneumonia, complicated skin and soft tissue infections, intra-abdominal infections, and febrile neutropenia. It is typically reserved for infections caused by susceptible bacteria when other antibiotics may not be appropriate.
Piperacillin works by interfering with bacterial cell wall synthesis, ultimately causing bacterial death. Tazobactam is a beta-lactamase inhibitor that protects piperacillin from being broken down by bacterial enzymes, extending the antibiotic's effectiveness against resistant organisms.
Zosyn is administered intravenously in healthcare settings. Serious adverse reactions can include allergic reactions (especially in penicillin-sensitive patients), Clostridioides difficile infection, and electrolyte abnormalities. Regular monitoring of kidney and liver function may be required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy