Zotepine
Zotepine is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and related psychotic disorders. It works by modulating dopamine and serotonin activity in the brain, helping to reduce psychotic symptoms such as hallucinations, delusions, and disorganized thinking. This medication is available in several countries including Japan and parts of Europe, though it is not approved for use in the United States.
Zotepine is an atypical antipsychotic used to treat schizophrenia by balancing dopamine and serotonin activity in the brain.
Key facts at a glance
- ATC
- N05AX11
- RxNorm
- 40003
- Generic
- Zotepine
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zotepine is primarily prescribed for the treatment of schizophrenia and acute psychotic episodes. It may also be used for other psychotic disorders where dopamine dysfunction is implicated.
As an atypical antipsychotic, zotepine works by blocking dopamine D2 receptors and serotonin 5-HT2A receptors in the brain. This dual action helps reduce positive symptoms of psychosis while potentially causing fewer movement-related side effects compared to older typical antipsychotics. It also has some noradrenaline reuptake inhibiting properties.
Common side effects may include sedation, weight gain, dry mouth, and orthostatic hypotension. Like other antipsychotics, it carries warnings about increased mortality in elderly patients with dementia-related psychosis. Patients should avoid alcohol and be monitored for metabolic changes during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy