Brexanolone
Zulresso is a prescription medication specifically approved for the treatment of postpartum depression (PPD) in adults. It is administered as a continuous intravenous infusion over 60 hours in a certified healthcare facility due to the risk of excessive sedation and sudden loss of consciousness.
Zulresso is a brand-name medication used to treat postpartum depression via a continuous 60-hour IV infusion under medical supervision.
Key facts at a glance
- RxNorm
- 2121782
- Generic
- Zulresso
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zulresso is indicated for the treatment of postpartum depression (PPD) in adults, which is a major depressive episode that occurs during pregnancy or within 4 weeks after delivery.
The exact mechanism of action is not fully established, but brexanolone (the active ingredient) is a neuroactive steroid that modulates GABA-A receptors, which may help restore hormonal balance and improve mood in postpartum depression.
Zulresso requires a 60-hour continuous IV infusion administered in a certified healthcare facility where patients can be monitored. Due to risks of excessive sedation and sudden loss of consciousness, patients require continuous monitoring and must not drive or operate machinery until they feel stable after treatment. It is not recommended for use during breastfeeding without careful consideration of risks and benefits.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy