Desoxycortone Pivalate
Zycortal is a long-acting injectable mineralocorticoid replacement therapy used in dogs to treat primary hypoadrenocorticism (Addison's disease). The medication contains desoxycorticosterone pivalate, which helps replace the hormones that the adrenal glands are unable to produce adequately. Dogs receiving Zycortal typically also require concurrent glucocorticoid supplementation for complete hormonal replacement.
Zycortal is a veterinary injectable medication used to provide mineralocorticoid replacement in dogs with Addison's disease.
Key facts at a glance
- RxNorm
- 1789685
- Generic
- Zycortal
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zycortal is indicated for the treatment of primary hypoadrenocorticism in dogs, a condition where the adrenal glands do not produce adequate amounts of corticosteroids, particularly aldosterone. It replaces the mineralocorticoid hormone to help maintain proper electrolyte balance, fluid levels, and blood pressure.
As a mineralocorticoid, Zycortal helps the kidneys retain sodium and excrete potassium, which is essential for maintaining normal electrolyte balance and blood pressure. The pivalate formulation provides a long-acting depot effect, typically requiring administration every 25-30 days.
Zycortal is administered by subcutaneous injection by a veterinarian. Dogs typically require concurrent oral glucocorticoid supplementation (such as prednisone). Overdose or incorrect dosing may lead to polydipsia, polyuria, edema, or hypertension. Regular monitoring of electrolytes and clinical response is necessary to adjust dosing appropriately. This medication is for veterinary use only in dogs.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy