Loncastuximab Tesirine
Zynlonta is an antibody-drug conjugate used to treat adults with relapsed or refractory large B-cell lymphoma after at least two prior lines of systemic therapy. It consists of an anti-CD19 antibody linked to a cytotoxic agent that specifically targets and destroys cancer cells expressing the CD19 protein. This medication is administered by intravenous infusion.
Zynlonta is a targeted therapy for relapsed or refractory large B-cell lymphoma that delivers a cytotoxic agent directly to CD19-expressing cancer cells.
Key facts at a glance
- RxNorm
- 2540970
- Generic
- Zynlonta
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with relapsed or refractory large B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, and DLBCL arising from low-grade lymphoma, after at least two prior lines of systemic therapy.
Zynlonta is an antibody-drug conjugate that binds to CD19, a protein on the surface of B-cells, and delivers a pyrrolobenzodiazepine cytotoxic agent directly into cancer cells, causing DNA damage and cell death.
Common side effects include fluid retention, fatigue, rash, and liver abnormalities. Pretreatment with corticosteroids is recommended before each infusion. Patients should be monitored for fluid accumulation, skin reactions, and infections. This medication may cause photosensitivity. Only available through a restricted distribution program.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy