Bupivacaine/Lidocaine
Zynrelef is a combination topical analgesic containing bupivacaine and meloxicam, designed for intraoperative application at the surgical site. It provides extended pain relief by combining a long-acting local anesthetic with an anti-inflammatory agent for managing post-operative discomfort.
Zynrelef is a dual-action topical analgesic used to manage pain during and after soft tissue and orthopedic surgical procedures.
Key facts at a glance
- RxNorm
- 2560324
- Generic
- Zynrelef
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Zynrelef is indicated for the management of postoperative pain in adults following soft tissue and/or orthopedic surgical procedures. It is applied directly to the surgical site during the procedure.
Zynrelef combines bupivacaine, a long-acting local anesthetic that blocks nerve signals to reduce pain locally, with meloxicam, an NSAID that reduces inflammation at the site. This dual mechanism provides both immediate and extended analgesic effects.
Zynrelef is for topical/intraoperative use only and should not be injected, instilled intra-articularly, or used in eyes. As with all local anesthetics and NSAIDs, there are risks of systemic absorption and potential adverse effects including cardiac, gastrointestinal, and renal complications. Healthcare providers should review patient history for contraindications before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy