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Cetirizine D

Published: July 26, 2026Updated: August 27, 2026

Zyrtec-D is a combination medication containing cetirizine (an antihistamine) and pseudoephedrine (a decongestant) used to treat seasonal allergy symptoms along with nasal and sinus congestion. It is commonly prescribed for adults and children who need relief from both allergic reactions and nasal stuffiness simultaneously.

Quick summary

Zyrtec-D combines an antihistamine with a decongestant to relieve allergy symptoms and nasal congestion.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

RxNorm
353102
Generic
Zyrtec-D
Class
brand-name
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Zyrtec-D is used to treat seasonal allergic rhinitis (hay fever) and perennial allergies, providing relief from symptoms such as sneezing, itchy/watery eyes, runny nose, and sinus congestion. It is particularly useful when patients experience both allergic symptoms and nasal stuffiness at the same time.

The cetirizine component blocks histamine H1 receptors in the body, reducing allergic reactions like itching, sneezing, and runny nose. The pseudoephedrine component acts as a nasal decongestant by causing vasoconstriction (narrowing of blood vessels) in the nasal passages, which reduces swelling and congestion.

Zyrtec-D may raise blood pressure and heart rate, so it should be used with caution in patients with hypertension, heart disease, or thyroid disorders. Pseudoephedrine is regulated in many regions due to its potential for misuse in producing illegal substances. The antihistamine component may cause drowsiness in some individuals, though cetirizine is generally considered less sedating than older antihistamines. Patients should consult their healthcare provider before use if they have diabetes, glaucoma, or prostate issues.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy