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Serum or Plasma Protein Electrophoresis with Bromocresol Green (BCG) Dye Binding Assay

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of different protein fractions in your blood, often used to identify abnormalities like protein disorders or conditions affecting protein synthesis.

Quick summary

["Helps detect conditions affecting blood proteins, such as multiple myeloma or liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56518-4
Short code
11DC 15M p chal SerPl-mCnc
Synonyms
11DC 15M p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates blood proteins based on size and charge, creating distinct bands. The BCG dye binding assay quantifies protein concentrations in each fraction, including albumin, globulins, and other proteins. This helps identify imbalances that may signal underlying health issues.

Why It’s Ordered

Your doctor may recommend this test if you have symptoms like unexplained weight loss, fatigue, or swelling, or if they suspect conditions like multiple myeloma, liver disease, or kidney problems. It’s also used as part of routine monitoring for certain chronic illnesses.

Sample Preparation

A blood sample is drawn, and the serum or plasma is processed for electrophoresis. The BCG dye binds to proteins, allowing precise measurement of their concentrations in each protein fraction.

Common Conditions Monitored

This test helps diagnose or monitor conditions such as multiple myeloma (a cancer of plasma cells), liver disease (affecting albumin production), kidney disease (altering protein filtration), and certain autoimmune disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis (BCG)

Frequently asked questions

Why might my results be checked for abnormalities?
Abnormal protein patterns may indicate conditions like multiple myeloma (where abnormal proteins accumulate), liver or kidney dysfunction (reducing or altering protein levels), or other metabolic disorders. Your doctor will interpret results in the context of your symptoms and medical history.
What does a high or low protein fraction mean?
High levels of certain globulins (e.g., immunoglobulins) may suggest immune system issues, while low albumin could point to liver or kidney problems. Your doctor will discuss specific findings with you.
How long will I need to fast for this test?
No fasting is required for this blood test. However, follow your doctor’s instructions regarding recent food or medication intake to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy