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Total Protein in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes important proteins like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Your blood protein levels can indicate overall health, hydration, and potential issues like kidney disease or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57503-5
Short code
11DC 1D p MTP SerPl-mCnc
Synonyms
11DC 1D p MTP SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Healthcare providers may order this test to check for conditions affecting protein production, kidney function, or fluid balance. It can also be part of routine blood work or when symptoms like swelling, fatigue, or unexplained weight changes appear.

What to Expect

A small blood sample is drawn from a vein, usually in your arm. The sample is processed to separate serum (the liquid part after clotting) for testing. Results are typically available within 1–3 days, depending on lab processing.

Normal vs. Abnormal Results

While exact ranges vary by lab, lower levels may suggest malnutrition, kidney disease, or liver problems, while higher levels could indicate dehydration, inflammation, or conditions like multiple myeloma.

Common Reasons for Testing

This test is often used alongside other blood tests (like albumin) to diagnose or monitor conditions such as chronic kidney disease, liver disease, or protein-losing syndromes (e.g., nephrotic syndrome).

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How long does it take to get my results?
Results are usually ready within 1–3 business days, but timing depends on your lab’s workflow. Ask your provider for an estimated turnaround when scheduling the test.
Can I eat or drink before this test?
No special preparation is needed for this test. However, avoid heavy meals or alcohol 24 hours before drawing blood to ensure accurate results.
What does it mean if my protein levels are low?
Low protein levels may signal underlying health issues like malnutrition, kidney disease, or liver dysfunction. Your provider will discuss findings with you and may recommend further testing or lifestyle changes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy