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Serum or plasma mass concentration of human serum albumin (HSA) via mass spectrometry

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of albumin, a protein found in your blood, which helps maintain proper fluid balance and supports the health of tissues.

Quick summary

["Albumin helps keep fluids in your bloodstream and supports tissue health; low levels may indicate kidney disease or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
13601-0
Short code
11DC 1h p 250 ug ACTH SerPl-mCnc
Synonyms
11DC 1h p 250 ug ACTH SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Albumin Does in Your Body

Albumin is a key protein in your blood that helps distribute nutrients, maintain fluid balance, and transport hormones and medications. It also contributes to your blood’s ability to clot and supports immune function. Low levels can signal conditions like kidney disease, liver problems, or severe dehydration, while high levels may be seen in conditions like dehydration or certain inflammatory states.

Why This Test Might Be Ordered

Your healthcare provider may order this test to check for kidney function, monitor chronic diseases (like liver disease or heart failure), assess nutritional status, or evaluate symptoms such as swelling, fatigue, or unexplained weight changes.

Common Reasons for Testing

Common reasons include diagnosing or monitoring kidney disease, liver disease, malnutrition, or fluid imbalances. It may also be used in patients with chronic conditions like heart failure or diabetes to track how well your body is retaining or losing albumin.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves a blood draw. Wear loose clothing for easy access to your arm.

Reference range

NCBI: ACTH 10-60 pg/mLN/A

Specimen: serum

Typically collected in the morning (8-10 AM). Inform your provider if taking steroid medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Albumin Level

Frequently asked questions

What does an abnormal albumin level mean?
Low albumin levels may indicate problems like kidney disease, liver failure, or malnutrition. High levels could suggest dehydration or certain inflammatory conditions. Your doctor will discuss results in the context of your overall health and symptoms.
How often will I need this test?
The frequency depends on your health condition. Some patients need it monthly, while others may only need it once a year or less. Your doctor will determine the schedule based on your needs.
Can I eat or drink before this test?
Most albumin tests do not require fasting, but always follow your doctor’s instructions. If fasting is required, avoid caffeine or heavy meals before the blood draw.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy