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17ohpamnmcnc

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of 17-hydroxyprogesterone in amniotic fluid to assess fetal adrenal gland function and screen for certain genetic conditions.

Quick summary

{"Measures 17-hydroxyprogesterone hormone in amniotic fluid","Used to screen for congenital adrenal hyperplasia (CAH) in the fetus","Helps doctors evaluate fetal adrenal gland development","Performed during pregnancy when there's family history of CAH","Involves amniocentesis procedure to collect the sample"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40754-4
Short code
17OHP Amn-mCnc
Synonyms
17OHP Amn-mCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

The 17-Hydroxyprogesterone (17-OHP) test in amniotic fluid is a prenatal diagnostic test that measures the concentration of 17-hydroxyprogesterone, a hormone produced by the adrenal glands, in the amniotic fluid that surrounds the fetus. This test is primarily used to screen for and diagnose congenital adrenal hyperplasia (CAH), a genetic condition that affects the adrenal glands' ability to produce cortisol and aldosterone hormones.

During the test, a sample of amniotic fluid is collected through a procedure called amniocentesis, where a thin needle is inserted into the uterus under ultrasound guidance to withdraw a small amount of fluid. The sample is then sent to a laboratory for analysis to measure the 17-OHP levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings2

Frequently asked questions

Why is this test performed during pregnancy?
This test is performed during pregnancy to screen for congenital adrenal hyperplasia (CAH) in the fetus. It is typically recommended when there is a family history of CAH, when a previous child was diagnosed with CAH, or when parents are known carriers of the CAH gene. Early detection allows healthcare providers to prepare for appropriate management and treatment options.
Is the amniocentesis procedure safe?
Amniocentesis is generally considered a safe procedure, but it does carry a small risk of complications, including miscarriage (approximately 1 in 300-500 procedures). The procedure is performed under ultrasound guidance to minimize risks. Your healthcare provider will discuss the risks and benefits with you before the test.
What do the test results mean?
Elevated levels of 17-hydroxyprogesterone in amniotic fluid suggest the fetus may have congenital adrenal hyperplasia. Normal levels indicate the fetus likely does not have CAH. Your healthcare provider will interpret the results in conjunction with other clinical information and may recommend additional testing or genetic counseling.
When will I get the test results?
The time to receive results may vary depending on the laboratory. Typically, results are available within a few days to a couple of weeks. Your healthcare provider will inform you of the timeline and discuss the results with you once they are available.
  1. 1
    Mayo Clinic - Congenital Adrenal HyperplasiaSource
  2. 2
    MedlinePlus - 17-HydroxyprogesteroneSource
  3. 3
    ACOG - Prenatal Genetic ScreeningSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy