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Published: August 9, 2026Updated: August 10, 2026

A blood test that measures the level of 17-hydroxyprogesterone, a hormone produced by the adrenal glands, to screen for and help diagnose congenital adrenal hyperplasia (CAH).

Quick summary

{"17-OHP is a hormone made by the adrenal glands","This test is mainly used to screen newborns for congenital adrenal hyperplasia (CAH)","A high level may indicate CAH, a genetic condition affecting hormone production","The test requires a simple blood draw from a vein or heel stick (for newborns)","Results help doctors diagnose adrenal gland disorders and guide treatment"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 10, 2026Editorial policy

Key facts at a glance

LOINC
32288-3
Short code
17-OHP
Synonyms
17OHP BS SerPl-sCnc
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or plain red top tube
Units
N/A
Ref low
0.2
Ref high
3
Critical range
— – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Immunoassay (Chemiluminescent or Enzyme-linked)
CPT
83498
SNOMED
31308002
Specimen volume
1.0-2.0 mL serum minimum
Stability
Room temperature: 24 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days
Hemolysis max
50
Lipemia max
300
Icterus max
20
TAT
24–72 hours
Order
routine

What is this test?

The 17-Hydroxyprogesterone (17-OHP) test measures the amount of 17-hydroxyprogesterone in your blood. This hormone is produced by the adrenal glands, which sit on top of your kidneys. 17-OHP is an intermediate product in the process of making cortisol, an important hormone that helps your body respond to stress, maintain blood pressure, and regulate metabolism.

Why is this test done?

The 17-OHP test is primarily performed for the following reasons: • **Newborn screening**: It is part of routine newborn screening programs to detect congenital adrenal hyperplasia (CAH) early • **Diagnosing CAH**: To confirm or rule out CAH in infants and children with symptoms • **Monitoring treatment**: To check how well treatment for CAH is working • **Evaluating adrenal function**: When a healthcare provider suspects adrenal gland problems

How is the test performed?

A healthcare professional will draw a small blood sample from a vein in your arm using a needle. For newborns, a small blood sample is usually taken from the heel (heel stick). The blood sample is then sent to a laboratory for analysis. The test is quick and generally causes minimal discomfort, similar to a typical blood draw.

How to prepare for the test?

In most cases, no special preparation is needed for the 17-OHP test. You can eat and drink normally before the test. However, certain medications, such as corticosteroids, may affect the test results. Always inform your healthcare provider about any medications or supplements you are taking. For infants, follow any specific instructions provided by your doctor.

Understanding your results

Normal 17-OHP levels vary based on age, gender, and laboratory reference ranges. Generally: • **Newborns**: Higher levels are normal in the first few days after birth • **Older children and adults**: Lower baseline levels are expected High levels of 17-OHP may suggest congenital adrenal hyperplasia (CAH). Your healthcare provider will interpret your results based on your specific situation, age, and other factors. Additional tests may be needed to confirm a diagnosis.

Reference range

Adults: 0.2-3.0 nmol/L; Newborns (term): <3.0 nmol/L; Preterm infants: <5.0 nmol/L; Children: 0.1-2.5 nmol/L depending on ageN/A

Specimen: serum

No special preparation required. Collect preferably in morning due to diurnal variation. Inform about any current medications especially corticosteroids or hormonal contraceptives

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is the 17-OHP test painful?
The test involves a needle stick to draw blood, which may cause brief discomfort or a slight pinch. For newborns, a heel stick is used, which may cause temporary discomfort but is generally well-tolerated.
How long does it take to get results?
Results are typically available within a few days to a week, depending on the laboratory. Your healthcare provider will contact you with the results or discuss them at your follow-up appointment.
What does a high 17-OHP level mean?
A high 17-OHP level often indicates congenital adrenal hyperplasia (CAH). However, slightly elevated levels can sometimes occur in premature newborns or due to other conditions. Your doctor will interpret the results in context and may order additional tests for confirmation.
Can adults have this test?
Yes, adults can have the 17-OHP test. It may be ordered if an adult shows symptoms of CAH or other adrenal disorders. Some adults with milder forms of CAH may not be diagnosed until adulthood.
Is fasting required for this test?
Fasting is usually not required for the 17-OHP test. You can eat and drink normally before the test unless your healthcare provider instructs otherwise.
  1. 1
    MedlinePlus - 17-HydroxyprogesteroneSource
  2. 2
    Mayo Clinic - Congenital Adrenal HyperplasiaSource
  3. 3
    March of Dimes - Newborn ScreeningSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy