3metyraminecsfscnc
This test measures the level of 3-methoxytyramine, a dopamine breakdown product, in cerebrospinal fluid to evaluate brain dopamine metabolism.
{"3-MT is a metabolite of dopamine, a key neurotransmitter","The test helps diagnose tumors that produce excess catecholamines","It may aid in evaluating neurodegenerative diseases like Parkinson's","CSF collection via lumbar puncture is required for this test","Results are compared against established reference ranges"}
Key facts at a glance
- LOINC
- 50139-5
- Short code
- 3-MT CSF
- Synonyms
- 3Me-tyramine CSF-sCnc
- Category
- chemistry
- Sample
- csf
- Container
- Polypropylene cryovial (CSF collection tube)
- Units
- N/A
- Ref low
- 15
- Ref high
- 45
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
- CPT
- 80349
- SNOMED
- 371441009
- Specimen volume
- 1-2 mL CSF
- Stability
- Store at -80°C; stable for up to 6 months. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 200
- TAT
- 168–336 hours
- Order
- routine
What is this test?
The 3-Methoxytyramine (3-MT) test measures the amount of 3-MT in your cerebrospinal fluid (CSF). 3-MT is a metabolite produced when dopamine, an important brain neurotransmitter, is broken down. By measuring 3-MT levels, doctors can assess how your body processes dopamine and identify certain neurological conditions.
Why is this test performed?
This test is primarily ordered to help diagnose and monitor conditions related to abnormal dopamine metabolism. It is particularly useful in detecting catecholamine-producing tumors such as pheochromocytoma and paraganglioma. Additionally, it may be used in research settings to evaluate neurodegenerative diseases like Parkinson's disease, where dopamine-producing neurons are affected.
How is the test performed?
The test requires a sample of cerebrospinal fluid, which is collected through a procedure called lumbar puncture (spinal tap). During this procedure, a healthcare provider inserts a thin needle between the bones in your lower back to draw out the CSF. The sample is then sent to a laboratory where it is analyzed using specialized techniques to measure 3-MT levels.
How to prepare?
Your healthcare provider will give you specific instructions before the test. You may need to avoid certain foods, medications, or supplements that could affect catecholamine levels. Be sure to inform your doctor about all medications you are taking. The lumbar puncture procedure itself may require you to lie flat for a period of time afterward.
Reference range
Reference range: 15-45 pmol/mL (may vary by laboratory method and reference population)N/A
No special preparation required. Patient should avoid caffeine and dopamine-active medications for 24 hours before collection if possible. Standard lumbar puncture preparation applies.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Is the lumbar puncture procedure painful?
How long does it take to get results?
Are there any risks associated with this test?
Do I need to fast before the test?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy