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3ohdodecanoatefreeserplscnc

Published: August 9, 2026Updated: August 10, 2026

A blood test that measures the level of a specific fatty acid to help diagnose metabolic disorders affecting how the body processes fats.

Quick summary

{"This test measures 3-hydroxydodecanoate, a type of fatty acid, in your blood","It helps doctors detect peroxisomal disorders, which affect energy production from fats","The test requires a simple blood sample, usually taken from a vein in your arm","Abnormal results may indicate genetic metabolic conditions requiring further testing","Your healthcare provider will explain what your specific results mean for your health"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 10, 2026Editorial policy

Key facts at a glance

LOINC
48753-8
Short code
3-OH-C12:0
Synonyms
3OH-dodecanoate.free SerPl-sCnc
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or EDTA plasma tube
Units
N/A
Ref low
0
Ref high
0.5
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
CPT
82017
SNOMED
127435009
Specimen volume
1.0 mL minimum (2.0 mL preferred)
Stability
Room temperature: 24 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days
Hemolysis max
50
Lipemia max
100
Icterus max
20
TAT
72–168 hours
Order
routine

What is this test?

The 3-Hydroxydodecanoate (3-OH-C12:0) test measures the amount of a specific fatty acid called 3-hydroxydodecanoate in your blood serum or plasma. This fatty acid is one of many that your body uses for energy. Normally, special cell structures called peroxisomes help break down these fatty acids. This test helps doctors check whether your peroxisomes are working properly.

Why might I need this test?

Your doctor may order this test if they suspect you have a peroxisomal disorder, such as Zellweger spectrum disorders. These are rare genetic conditions where the body cannot properly break down certain fatty acids. Symptoms may include developmental delays, vision problems, hearing loss, liver issues, or distinctive facial features. In newborns, this test is sometimes part of routine screening to catch these conditions early.

How is the test done?

A healthcare professional will draw a small amount of blood from a vein in your arm using a needle. The blood will be collected in a tube and sent to a laboratory for analysis. You may feel a brief sting when the needle goes in or out. The risk of complications is very low. Fasting is not typically required for this test, but follow any specific instructions your doctor gives you.

What do the results mean?

Normal results mean your peroxisomes are likely functioning properly. High levels of 3-hydroxydodecanoate may indicate a peroxisomal disorder. However, your doctor will consider your symptoms, other test results, and your medical history when interpreting your results. They may recommend additional tests to confirm a diagnosis.

Reference range

Reference range: 0.00-0.50 µmol/L (laboratory-specific)N/A

Specimen: serum

No special preparation required. Collect sample using standard venipuncture technique. Avoid hemolysis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is this test painful?
The test involves a needle prick to draw blood, which may cause brief discomfort similar to a pinprick. The pain is usually minimal and only lasts a moment.
How long does it take to get results?
Results typically take a few days to a week, depending on the laboratory. Your healthcare provider will contact you when results are ready or discuss them at your follow-up appointment.
Do I need to fast before this test?
Fasting is generally not required for this specific test, but always follow your doctor's specific instructions. Some other blood tests may require fasting, so ask your healthcare provider about preparation.
What happens if my results are abnormal?
An abnormal result does not necessarily mean you have a serious condition. Your doctor will interpret the results in context and may order additional tests, such as genetic testing or other metabolic markers, to confirm a diagnosis.
Can this test be done on children?
Yes, this test can be performed on individuals of any age, including newborns. In fact, it is often included in newborn screening panels to detect metabolic disorders early.
  1. 1
    MedlinePlus - Peroxisomal DisordersSource
  2. 2
    Mayo Clinic Laboratories - 3-Hydroxyacyl-CoA DehydrogenaseSource
  3. 3
    National Institute of Neurological Disorders and Stroke - Zellweger SyndromeSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy